Journal: Human Molecular Genetics

Article Title: Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease

doi: 10.1093/hmg/ddw429

Figure Lengend Snippet: Weight loss, motor performance and survival of hPFN1 G118V mice compared to hPFN1 WT and non-TG mice. ( A ) Body weights presented from P100 to P260. The weight of hPFN1 G118V mice began to drop from PD 150, n = 12-15. A repeated measure ANOVA followed by a Student-Newman-Keuls test, * P < 0.05. ( B ) Rotarod performance, n = 15/group, * P< 0.05. ( C ) Stride length measured in centimeters (cm) at P160 shows significant stride shortening in hPFN1 G118V mice ( n = 10), repeated measure of ANOVA followed by Student-Newman-Keuls test **** P< 0.0001. ( D ) Kaplan-Meier survival plot of male and female hPFN1 G118V mice compared to hPFN1 WT ( n = 15), M = Males ( n = 43), F = Females ( n = 26). For A–C, data are presented as mean ± SEM. Asterisks in A, B, and C denote significant difference in weight, latency in rotarod, and stride length between hPFN1 G118V mice and non-TG or hPFN1 WT mice. Female mice survival is significantly shorter than males, as assessed with Kaplan-Meier analysis of survival with logrank (Mantel-Cox) test.

Article Snippet: The Kaplan-Meier analysis of survival data suggested a significant difference in lifespan between hPFN1 G118V male and female mice using the logrank (Mantel-Cox) test (Chi-Square +7.102; P value = 0.0077).

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